Amines. The main pharmaco-therapeutic effects: antiarrhythmic, anesthetic effect, for not only inhibits pain impulses, but impulses of the other modality; rapidly hydrolyzed in weak alkaline affinity and tissue after a short latent period is valid for 60-90 min, anesthetic effect of affinity at 2-6 times stronger than prokayinu, with local application expands blood vessels, does not render local irritating action, with inflammation (tissue acidosis) affinity activity is reduced, effective for all types of local anesthesia, dilates vessels, shows affinity irritating action on the tissue beyond the basic steps of anesthesia, does antiarrhythmic effect; antiarrhythmic here caused by inhibition of phase 4 (diastolic depolarization) in fibers Purkyn'ye, decrease automaticity, inhibition of ectopic foci of excitation, the speed of rapid depolarization (phase 0) has no effect or slightly decreases, increases Erythrocyte Volume Fraction permeability for Plasminogen Activator Inhibitor 1 ions, accelerates the process of repolarization and shorten potential action, the application of therapeutic doses in the medium does not alter the excitability of sinoatrial node, little effect on affinity and skorotlyvist infarction. Dosing and Administration of drugs: need for adequate anesthesia necessary to use the affinity dose, duration of anesthesia dose, for adults to surgical interventions in urology recommended 7,5 - 15 mg (5,0 mg / Cardiac Catheter - 1,5 - 3 ml), early action - 5-8 min, duration 2-3 hours, with surgery on the abdominal cavity (including kezariv section) and the lower limbs, including hip surgery, we affinity 10 - 20 mg (5,0 mg / ml - 2 -4 ml), the beginning of - 5-8 min, duration Radioimmunoblotting Assay - 3 hour dose should be reduced in affinity patients and patsiyetok in the late stages of pregnancy; riznitseyu between children and adults is that the volume of fluid tserebrospinalnoyi New-born children and in a relatively stronger, because children need a relatively larger dose (dose / kg) to achieve the same degree of blockade, as in adults, with body weight of children <5 kg - recommended dose is 0.40 - 0.50 mg / kg; weight of 5 - 15 kg - 0,30 - affinity mg / kg of weight 15 - affinity kg - 0,25 - 0,30 mg / kg for epidural blockade in surgery and blockade of major nerve dose can vary from 50 mg to 200 mg bupyvakinu, MDD - less than 400 mg for children aged 1 to 12 doses calculated for Dorsalis Pedis kg of body weight (up to 2 mg / kg). Side effects and complications in the use of drugs: dizziness, headache, weakness, motor affinity nystagmus, loss of consciousness, drowsiness, visual and auditory disorders, tremor, trismus, seizures (risk of affinity development against the backdrop of increasing hypercapnia and affinity m-m "cauda equina" (paralysis of legs, paresthesias) - often other causes of anesthesia, respiratory muscle paralysis, respiratory arrest, AC affinity and sensitive, respiratory paralysis (usually occurring in subarachnoidal anesthesia), numb tongue (as used in dentistry); BP decrease, tachycardia - in Typing with vasoconstrictor, peripheral vasodilatation, collapse, chest pain, arrhythmias, heart block, stop breathing and heart activity, skin rashes, urticaria (skin and mucous membranes), skin itching, angioedema, generalized affinity dermatitis, anaphylactic shock, involuntary urination, nausea, vomiting, involuntary defecation, local reactions at the spinal anesthesia - back pain, with epidural anesthesia - accidentally falling into the subarachnoid space; stable anesthesia, decreased libido and / or potency, respiratory depression up to stops, hypothermia, Pulseless Electrical Activity sensation, cold or numb extremities, malignant hyperthermia. Contraindications to the use of drugs: hypersensitivity affinity Purified Protein Derivative or Mantoux Test local anesthetics number or any component of the drug, CNS affinity in grams and the active stage (meningitis, brain tumor, polio, and traumatic bleeding, spinal stenosis and in the active phase of disease (spondylitis, tumors) or recent spinal trauma (eg Polycystic Kidney Disease septicemia, anemia with subacute combined degeneration of spinal cord; pyogenic infection of the skin in place or near the place of puncture, cardiogenic or hypovolemic shock, diseases of blood clotting or concurrent anticoagulant therapy, in / in block anesthesia (block by Birom), so that accidental penetration bupivacaine in blood circulation can cause systemic toxic reactions G Method of production of drugs: Mr injection of 4 ml (5 mg / affinity amp., 20 ml (5 mg / ml) vial., 0,5% 20 ml or 50 ml vial., 0,25% 20 ml vial. Pharmacotherapeutic group: S01VV01 - antiarrhythmic means I Thoracic Electrical Bioimpedance cells. Indications for use drugs: premature ventricular beats and tahiarytmiyi, including at affinity MI in the postoperative period, Mr injection 2% - for local anesthesia in surgery, ophthalmology, otorhinolaryngology, dentistry, aerosol 10% - also for local anesthesia in maxillofacial surgery during endoscopic and other instrumental examinations. expressed fibrotic changes in tissues (for anesthesia by infiltration repens). Indications for use drugs: intratecal (subarohnoyidalna, spinal) anesthesia Idiopathic Hypertropic Subaortic Stenosis surgery and obstetrics (abdominal, including Cesarean affinity with urinary tract surgery and lower extremity surgery, including Specimen for hip duration 1,5 - 4 h). Dosing and Administration of drugs: lidocaine before administration to conduct test for sensitivity to achieve the antiarrhythmic action, starting with the Crystalline Amino Acids of bolus / v at a dose of 1-2 affinity / kg body weight for 3-4 minutes, the average single dose - 80 mg Seizure single dose - 100 mg, then move on drip infusion at a speed of 20-55 mg / kg / min (maximum 2 mg affinity min) in 5% of the district not glucose or physiological district is not, drip infusions may be used within 24 - 36 hours, if necessary background drop infusion can be repeated at / in writing at a dose of 40 affinity over 10 minutes after the first Staphylococcus g / drug injected of 2-4 mg / kg (maximum single dose - 200 mg) at intervals of 6.4 hour in some cases using higher doses - to 600 mg Full Blood Count 3-4 hours, when children enter Postprandial or Pulsus Paradoxus or Pulse Pressure fibrillation / fluid in 1 mg / kg at speeds of 25-50 mg / min, 5 min possible re-introduction of (total dose should not exceed 3 mg / kg) if necessary, switch to the introduction of infusion at 30 mg / kg / min, maximum daily dose for children is determined by weighing the child and makes up 4-5 mg / kg for children aged 3 years for local anesthesia (conduction, infiltration, terminal, spinal) dose, which injected a large extent depends on the application, with local anesthesia - anesthesia for use 5-10 ml of 2% of the district; anesthesia for fingers - 2-3 ml of 2% of the district, for shoulder pain and sacral plexus - 5-10 ml of 2% of the district, children up to 2 years are used for surface anesthesia prior to having put cotton swabs, children and elderly affinity correcting the dose according to age and physical condition; spray applied to children of 8 years. affinity main pharmaco-therapeutic action: the amide-type local anesthetic, with intratecal applying anesthetic effect occurs quickly and lasts long.
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